Article

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

2022-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria which is inherent to both familial and sporadic forms of the disease. Small-molecule inhibitors t...

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Literature Corpus work: 0d660b79-2ee2-56ff-87b1-5dedef4b5c2c
DOI: 10.1101/2022.09.13.507798

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