Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions.

Biochemical Society transactions - 20 Dec 2019

Dufner Almut, Knobeloch Klaus-Peter

Abstract excerpt

Protein modification by ubiquitin is one of the most versatile posttranslational regulations and counteracted by almost 100 deubiquitinating enzymes (DUBs). USP8 was originally identified as a growth regulated ubiquitin-specific protease and is like many other DUBs characterized by its multidomain architecture. Besides the catalytic domain, specific protein-protein interaction modules were characterized which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Cilia
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Endosomes

Share to Mitophagy

Share to T-Lymphocytes

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 31845722
DOI: 10.1042/BST20190527
PMCID: PMC6925526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions.PMID 31845722Read ↗

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanismsSemantic proximity Read ↗

Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer developmentSemantic proximity Read ↗

USP3 : Key deubiquitylation enzyme in human diseasesSemantic proximity Read ↗

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the SpotlightSemantic proximity Read ↗

USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunitiesSemantic proximity Read ↗

Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and CancersSemantic proximity Read ↗

La FAM fatale: USP9X in development and diseaseSemantic proximity Read ↗

Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutationsSemantic proximity Read ↗

Impact of USP8 Gene Mutations on Protein Deregulation in Cushing DiseaseSemantic proximity Read ↗

Deubiquitinases as novel therapeutic targets for diseasesSemantic proximity Read ↗

Deubiquitinating enzymes in cellular signaling and disease regulationSemantic proximity Read ↗

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.