Article

Refined USP25/28 inhibitors with enhanced selectivity towards c-Myc driven squamous lung cancer cells

2026-03-20

Abstract excerpt

<h4>SUMMARY</h4> The ubiquitin specific protease 28 (USP28) is implicated in tumorigenesis by controlling the turnover of substrates including the oncogene c-MYC and the ubiquitin ligase FBW7. Here, we describe small molecule inhibitors of USP25 and USP28, leading to cancer cell cycle arrest and death. However, genetic deletion of USP25/28 does not replicate this effect. An integrated –omics approach revealed off...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6cc0cec-3ef5-52e9-8bd0-b9641d8bcb40
DOI: 10.64898/2026.03.17.712179

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Refined USP25/28 inhibitors with enhanced selectivity towards c-Myc driven squamous lung cancer cellsDOI 10.64898/2026.03.17.712179Read

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinomaSemantic proximity Read

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule BenzosulfonamidesSemantic proximity Read

Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletionSemantic proximity Read

USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell CarcinomaSemantic proximity Read

The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancerSemantic proximity Read

USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cellsSemantic proximity Read

Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic functionSemantic proximity Read

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cellsSemantic proximity Read

USP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3KSemantic proximity Read

USP7: Novel Drug Target in Cancer TherapySemantic proximity Read

Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activitySemantic proximity Read

USP48 stabilizes YBX1 to enforce a Wnt-driven stemness circuit and osimertinib resistance in EGFR-mutant NSCLC.Semantic proximity Read