Article

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

2018-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Biomedical scientists face major challenges in developing novel drugs for unmet medical needs. Only a small fraction of early drug programs progress to the market, due to safety and efficacy failures, despite extensive efforts to predict drug and target safety as early as possible using a variety of assays in vitro and in preclinical species. In principle, characterizing the effect of natural va...

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Literature Corpus work: af2dd014-4eaf-527e-bdfd-71fbcc200f83
DOI: 10.1101/285858

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