Article
The support of human genetic evidence for approved drug indications.
Nature genetics - 1 Aug 2015
Nelson Matthew R, Tipney Hannah, Painter Jeffery L, Shen Judong, Nicoletti Paola, Shen Yufeng, Floratos Aris, Sham Pak Chung, Li Mulin Jun, Wang Junwen, Cardon Lon R, Whittaker John C, Sanseau Philippe
Abstract excerpt
Over a quarter of drugs that enter clinical development fail because they are ineffective. Growing insight into genes that influence human disease may affect how drug targets and indications are selected. However, there is little guidance about how much weight should be given to genetic evidence in making these key decisions. To answer this question, we investigated how well the current archive of genetic...
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