Article

Human genetic evidence enriched for side effects of approved drugs

2023-12-13

Abstract excerpt

Safety failures are an important factor in low drug development success rates. Human genetic evidence can select drug targets causal in disease and enrich for successful programs. Here, we sought to determine whether human genetic evidence can also enrich for labeled side effects (SEs) of approved drugs. We combined the SIDER database of SEs with human genetic evidence from genome-wide association studies, Mendeli...

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Literature Corpus work: a8d49419-dcb1-5fc4-9a9f-332d254667b8
DOI: 10.1101/2023.12.12.23299869

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