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Article

Safetyome and specialized panels for over 3,000 phenotypes: a systematic and translational approach using human genetics and pharmacology.

Toxicological sciences : an official journal of the Society of Toxicology - 2 Mar 2026

Liu Xin, Chen Yen-Wei, Xu Xiao, Smith David, Fan Fan

Abstract excerpt

Drug candidates are often evaluated for their activities against unexpected targets (off-targets), to either prospectively flag potential hazards or to provide mechanistic insights for a given phenotype. The in vitro to in vivo translatability is critical when selecting which "phenotypically consequential" off-targets to screen. To this end, human genetics and indication-based pharmacology offer unraveled...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41712761
DOI: 10.1093/toxsci/kfag021
PMCID: PMC13016935

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