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Article

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.

Current opinion in pharmacology - 1 Oct 2003

Zambrowicz Brian P, Turner C Alexander, Sands Arthur T

Abstract excerpt

One of the major challenges for the pharmaceutical industry is to develop innovative drugs to new targets from the human genome. A systematic approach for target selection could significantly increase the rate of successful new drug development, thereby enhancing industry productivity. It has previously been shown that mouse knockout phenotypes for the targets of the 100 best-selling pharmaceutical drugs...

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PMID: 14559104
DOI: 10.1016/j.coph.2003.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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