Article

Flipping the odds of drug development success through human genomics

2017-07-30

Abstract excerpt

Drug development depends on accurately identifying molecular targets that both play a causal role in a disease and are amenable to pharmacological action by small molecule drugs or bio-therapeutics, such as monoclonal antibodies. Errors in drug target specification contribute to the extremely high rates of drug development failure. Integrating knowledge of genes that encode druggable targets with those that influe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67c33d8c-4b8d-550b-b00b-e3ff41bd01be
DOI: 10.1101/170142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Flipping the odds of drug development success through human genomicsDOI 10.1101/170142Read

Human Genomics and Drug Development.Semantic proximity Read

The druggable genome and support for target identification and validation in drug developmentSemantic proximity Read

The support of human genetic evidence for approved drug indications.Semantic proximity Read

The druggable genome and support for target identification and validation in drug development.Semantic proximity Read

Refining the impact of genetic evidence on clinical successSemantic proximity Read

Genetics in drug discovery and development: challenge and promise of individualizing treatment in common complex diseases.Semantic proximity Read

Refining the impact of genetic evidence on clinical success.Semantic proximity Read

Human genetics as a foundation for innovative drug developmentSemantic proximity Read

A comprehensive map of molecular drug targets.Semantic proximity Read

Translating Human Genetics into Novel Drug Targets.Semantic proximity Read

Using the HapMap in drug development.Semantic proximity Read

A genomic "roadmap" to "better" drugs.Semantic proximity Read