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Article

Tissue-specific genetic features inform prediction of drug side effects in clinical trials.

Science advances - 1 Sept 2020

Duffy Áine, Verbanck Marie, Dobbyn Amanda, Won Hong-Hee, Rein Joshua L, Forrest Iain S, Nadkarni Girish, Rocheleau Ghislain, Do Ron

Abstract excerpt

Adverse side effects often account for the failure of drug clinical trials. We evaluated whether a phenome-wide association study (PheWAS) of 1167 phenotypes in >360,000 U.K. Biobank individuals, in combination with gene expression and expression quantitative trait loci (eQTL) in 48 tissues, can inform prediction of drug side effects in clinical trials. We determined that drug target genes with five genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32917698
DOI: 10.1126/sciadv.abb6242
PMCID: PMC11206454

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