Article

CCR5-del32 is not deleterious in the homozygous state in humans

2019-10-02

Abstract excerpt

Recently, Wei and Nielsen 1 reported an analysis of UK Biobank data which suggested that the well-known HIV-protective variant CCR5-del32 is associated with a 21% increase in all-cause mortality. We demonstrate, using two well-powered population samples in Iceland and Finland with extensive health data and death information, neither an effect on mortality nor increase in risk of any disease. Further reexamination...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af0b5b36-5824-5abc-b2ab-5ef7d9becfc0
DOI: 10.1101/788117

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CCR5-del32 is not deleterious in the homozygous state in humansDOI 10.1101/788117Read

No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohortSemantic proximity Read

Association between <i>CCR5</i>-Δ32 homozygosity and mortality in 37,650 participants from three U.S.-based cohortsSemantic proximity Read

Reported CCR5-∆32 deviation from Hardy-Weinberg equilibrium is explained by poor genotyping of rs62625034Semantic proximity Read

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.Semantic proximity Read

Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study.Semantic proximity Read

CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.Semantic proximity Read

Frequency of a mutated CCR-5 allele (delta32) among Italian healthy donors and individuals at risk of parenteral HIV infection.Semantic proximity Read

"Ground truth" for selection on CCR5-Delta32.Semantic proximity Read

New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable?Semantic proximity Read

CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?Semantic proximity Read

The case for selection at CCR5-Delta32.Semantic proximity Read

Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Delta32 deletion.Semantic proximity Read