Article

No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort

2019-10-02

Abstract excerpt

A recent study reported that a 32-base-pair deletion in the CCR5 gene (CCR5-∆32) is deleterious in the homozygous state in humans. Evidence for this came from a survival analysis in the UK Biobank cohort, and from deviations from Hardy-Weinberg equilibrium at a polymorphism tagging the deletion (rs62625034). Here, we carry out a joint analysis of whole-genome genotyping data and whole-exome sequencing data from t...

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Literature Corpus work: 00806443-8d5d-59b8-b4a9-bf25c52fd777
DOI: 10.1101/787986

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