Article
The case for selection at CCR5-Delta32.
PLoS biology - 1 Nov 2005
Sabeti Pardis C, Walsh Emily, Schaffner Steve F, Varilly Patrick, Fry Ben, Hutcheson Holli B, Cullen Mike, Mikkelsen Tarjei S, Roy Jessica, Patterson Nick, Cooper Richard, Reich David, Altshuler David, O'Brien Stephen, Lander Eric S
Abstract excerpt
The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequency (5%-14%) in Europe as a result of strong positive selection, perhaps by such selective agents as the bubonic plague or smallpox during the Middle Ages. This...
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