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Article

"Ground truth" for selection on CCR5-Delta32.

Trends in genetics : TIG - 1 Jun 2006

Hedrick Philip W, Verrelli Brian C

Abstract excerpt

A much-celebrated story of positive selection in the human genome is the 32-bp deletion in the chemokine receptor CCR5, a variant that confers resistance to AIDS. This variant was postulated to be a relatively recent response to plague or smallpox. New research shows that the frequency of CCR5-Delta32 in Bronze Age samples is similar to that seen today, pushing the observed age of the allele back to at least 3000...

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Source

Identifiers

PMID: 16678299
DOI: 10.1016/j.tig.2006.04.007

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

"Ground truth" for selection on CCR5-Delta32.PMID 16678299Read ↗

The case for selection at CCR5-Delta32.Semantic proximity Read ↗

The evolutionary history of the CCR5-Delta32 HIV-resistance mutation.Semantic proximity Read ↗

Legacy of a magic gene-CCR5-∆32: From discovery to clinical benefit in a generation.Semantic proximity Read ↗

Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.Semantic proximity Read ↗

HIV-1 protecting CCR5-Delta32 allele in medieval Poland.Semantic proximity Read ↗

Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons.Semantic proximity Read ↗

Reported CCR5-∆32 deviation from Hardy-Weinberg equilibrium is explained by poor genotyping of rs62625034Semantic proximity Read ↗

Distribution of the CCR5 gene 32-basepair deletion in West Europe. A hypothesis about the possible dispersion of the mutation by the Vikings in historical times.Semantic proximity Read ↗

More about the Viking hypothesis of origin of the delta32 mutation in the CCR5 gene conferring resistance to HIV-1 infection.Semantic proximity Read ↗

Ancient DNA Investigation of a Medieval German Cemetery Confirms Long-Term Stability of CCR5-Δ32 Allele Frequencies in Central Europe.Semantic proximity Read ↗

New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable?Semantic proximity Read ↗

Could the CCR5-Delta32 mutation be protective in SARS-CoV-2 infection?Semantic proximity Read ↗

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