Article

Two Novel Pde11a Genetic Variants Increase Tau Phosphorylations in Early-onset Alzheimer's Disease

2020-06-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Alzheimer’s disease (AD) is a leading cause of dementia in the elderly and has become a major health issue. However, a large number of genetic risk factors remain undiscovered. <bold>Methods: </bold>To identify novel risk genes and better understand the molecular pathway underlying AD, whole-exome sequencing (WES) was performed in 215 early-onset AD (EOAD) patie...

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Literature Corpus work: aecb91e6-2f22-50ee-8846-96e8e63811e7
DOI: 10.21203/rs.3.rs-36875/v1

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