Article

Two Novel PDE11A Genetic Variants Increase Tau Phosphorylations in Early-onset Alzheimer's Disease

2020-08-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Alzheimer’s disease (AD) is a leading cause of dementia in the elderly and has become a major health issue. However, a large number of genetic risk factors remain undiscovered. <bold>Methods: </bold>To identify novel risk genes and better understand the molecular pathway underlying AD, whole-exome sequencing (WES) was performed in 215 early-onset AD (EOAD) patie...

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Literature Corpus work: 2955ca86-bac1-5bf2-9a68-084a0c788189
DOI: 10.21203/rs.3.rs-60929/v1

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