Article

Targeted sequencing on neurodegenerative genes identified novel causal and risk variants of familial Alzheimer's disease

2020-04-29

Abstract excerpt

<title>Abstract</title> <p>Background Mutations of <italic>APP</italic>, <italic>PSEN1</italic> and <italic>PSEN2</italic> only account for a small portion of familial Alzheimer’s disease (AD), leaving the genetic factors for the rest AD families unexplained. Neurodegenerative diseases have some neuropathological, clinical and genetic crossover. The effect of neurodegenerative genes to familial AD remains unknow...

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Literature Corpus work: efb1aece-1d43-55db-845f-0b783d35d5c6
DOI: 10.21203/rs.3.rs-24070/v1

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