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Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

23 Mar 2024

Abstract excerpt

Abstract Meta-analysis of genome-wide association study data has implicated PDE4B in the pathogenesis of Alzheimer’s disease (AD), the leading cause of senile dementia. PDE4B encodes one of four subtypes of cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase-4 (PDE4A–D). To interrogate the involvement of PDE4B in the manifestation of AD-related phenotypes, the effects of a hypomorphic mutation (...

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Share to Alzheimer's disease research and treatments
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PMID: 38521860
DOI: 10.1038/s41386-024-01852-z

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