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APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease

25 Sept 2019

Abstract excerpt

The number of patients with Alzheimer’s disease (AD) is rapidly increasing in Asia. Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) genes can cause autosomal dominant forms of early-onset AD (EOAD). Although these genes have been extensively studied, variant classification remains a challenge, highlighting the need to colligate mutations across populations. In this...

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PMID: 31557888
DOI: 10.3390/ijms20194757

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