Article

<i>MC1R</i> loss-of-function is associated with accelerated Parkinson’s disease motor decline

2025-12-29

Abstract excerpt

<h4>Background</h4> Melanocortin 1 receptor ( MC1R ) is a key regulator of pigmentation. Previous studies have linked MC1R loss-of-function variants to increased risk for Parkinson ’ s disease (PD); however, whether they are associated with PD progression remains unknown. Using data from the Parkinson ’ s Progression Markers Initiative (PPMI) cohort, we aimed to test whether MC1R loss-of-function variants, e...

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Literature Corpus work: aec39567-a379-5625-a905-8864aa22153d
DOI: 10.64898/2025.12.26.25343003

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