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Article

Association of cholesterol and glycemic state biomarkers with phenotypic variation and Parkinson's disease progression: The Oxford Discovery cohort.

Journal of Parkinson's disease - 1 May 2025

Ho Chiu Nicholas Kwan, Lawton Michael, Zerenner Tanja, Morovat Alireza, Welch Jessica, Razzaque Jamil, Hu Michele T, Ben-Shlomo Yoav

Abstract excerpt

BackgroundParkinson's disease (PD) has marked phenotypic variability. Increased lipids have been suggested as being neuroprotective whilst hyperglycemia may increase α-synuclein aggregation.ObjectiveWe have tested whether high total cholesterol and high-density lipoprotein cholesterol (HDL-C) and low levels of fructosamine are associated with better PD phenotypes and predict less rapid...

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Identifiers

PMID: 40221968
DOI: 10.1177/1877718X251323914
PMCID: PMC13347451

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