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Article

Progression in the LRRK2-Asssociated Parkinson Disease Population.

JAMA neurology - 1 Mar 2018

Saunders-Pullman Rachel, Mirelman Anat, Alcalay Roy N, Wang Cuiling, Ortega Roberto A, Raymond Deborah, Mejia-Santana Helen, Orbe-Reilly Martha, Johannes Brooke A, Thaler Avner, Ozelius Laurie, Orr-Urtreger Avi, Marder Karen S, Giladi Nir, Bressman Susan B

Abstract excerpt

Importance: Few prospective longitudinal studies have evaluated the progression of Parkinson disease (PD) in patients with the leucine-rich repeat kinase 2 (LRRK2 [OMIM 609007]) mutation. Knowledge about such progression will aid clinical trials. Objective: To determine whether the longitudinal course of PD in patients with the LRRK2 mutation differs from the longitudinal course of PD in patients without the...

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Identifiers

PMID: 29309488
DOI: 10.1001/jamaneurol.2017.4019
PMCID: PMC5885854

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