Article
The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2017
Pont-Sunyer Claustre, Tolosa Eduardo, Caspell-Garcia Chelsea, Coffey Christopher, Alcalay Roy N, Chan Piu, Duda John E, Facheris Maurizio, Fernández-Santiago Rubén, Marek Kenneth, Lomeña Francisco, Marras Connie, Mondragon Elisabet, Saunders-Pullman Rachel, Waro Bjorg
Abstract excerpt
BACKGROUND: Asymptomatic, nonmanifesting carriers of leucine-rich repeat kinase 2 mutations are at increased risk of developing PD. Clinical and neuroimaging features may be associated with gene carriage and/or may demarcate individuals at greater risk for phenoconversion to PD. OBJECTIVES: To investigate clinical and dopamine transporter single-photon emission computed tomography imaging characteristics of...
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