Article

Single-cell landscape reveals NAMPT mediated macrophage polarization that regulate smooth muscle cell phenotypic switch in pulmonary arterial hypertension

2023-07-04

Abstract excerpt

<h4>Rationale</h4> Pulmonary arterial hypertension (PAH) is a progressive and lethal disease that leads to elevated pulmonary vascular resistance and right ventricular failure. The phenotypic switching of pulmonary arterial smooth muscle cells (SMCs) plays a crucial role in the pathological progression of PAH. However, the underlying mechanism of SMC phenotypic modulation remains unclear. <h4>Objectives</h4> We...

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Literature Corpus work: aea42f4a-281e-5622-8bf6-9fadea234b7d
DOI: 10.1101/2023.07.04.547668

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