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Single-cell characterization of the immune heterogeneity of pulmonary hypertension identifies novel targets for immunotherapy

10 Feb 2025

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a critical cardiopulmonary vascular disorder marked by the progressive elevation of pulmonary artery pressure, increased pulmonary vascular resistance, and eventual right heart failure. Research has shown that various immune cells play a significant role in the pathogenesis of PAH, both in patients diagnosed with the condition and in experimental models of PAH. Cell–cell...

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PMID: 39930365
DOI: 10.1186/s12865-025-00684-w

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