Article

BST2 induces vascular smooth muscle cell plasticity and phenotype switching during cancer progression

2024-09-14

Abstract excerpt

<h4>Background</h4> Smooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases, but their role in tumorigenesis is unknown. We investigated whether and how SMC diversity and plasticity plays a role in tumor angiogenesis and the tumor microenvironment. <h4>Methods and Results</h4> We use SMC-specific lineage-tracing mouse models and single cell RNA s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b521905-f005-5e74-9e90-8f474849850c
DOI: 10.1101/2024.09.10.612298

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BST2 induces vascular smooth muscle cell plasticity and phenotype switching during cancer progressionDOI 10.1101/2024.09.10.612298Read

Atherosclerosis is a smooth muscle cell-driven tumor-like diseaseSemantic proximity Read

Single-cell landscape reveals NAMPT mediated macrophage polarization that regulate smooth muscle cell phenotypic switch in pulmonary arterial hypertensionSemantic proximity Read

A genome-wide, single-cell analysis of vascular smooth muscle cell plasticitySemantic proximity Read

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read

Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular diseaseSemantic proximity Read

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.Semantic proximity Read

Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage Pathogenesis.Semantic proximity Read

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis.Semantic proximity Read

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.Semantic proximity Read

Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease riskSemantic proximity Read

<i>Klf4</i> -dependent pivotal role of smooth muscle-derived <i>Gli1</i> <sup>+</sup> lineage progenitor cells in lung cancer progressionSemantic proximity Read

Smooth muscle cell phenotypic switching in atherosclerosis.Semantic proximity Read