Article
Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension.
Cardiovascular research - 28 Oct 2025
Cober Nicholas D, McCourt Emma, Godoy Rafael Soares, Deng Yupu, Schlosser Ken, Qamsari Elmira Safaie, Azami Jalil, Salehisiavashani Elham, Cook David P, Lemay Sarah-Eve, Klouda Timothy, Yuan Ke, Bonnet Sébastien, Stewart Duncan J
Abstract excerpt
AIMS: Pulmonary arterial hypertension (PAH) is a lethal pulmonary vascular disease characterized by arteriolar pruning and occlusive vascular remodelling leading to increased pulmonary vascular resistance and eventually right heart failure. While endothelial cell (EC) injury and apoptosis are known triggers for this disease, the mechanisms by which they lead to complex arterial remodelling remain obscure. We...
Topics
- Vascular Remodeling
- Animals
- Pulmonary Artery
- Disease Models, Animal
- Pulmonary Arterial Hypertension
- Endothelial Cells
- Transcriptome
- Arterial Pressure
- Single-Cell Analysis