Article

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

2024-05-15

Abstract excerpt

Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMC) and adventitial fibroblasts (PAAF). Mechanisms driving the transition to a diseased phenotype remain elusive. Utilizing a combination of transcriptomic and proteomic profiling, along with phenotyping of source-matched cells from healthy controls and individ...

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Literature Corpus work: d3828727-4557-5667-b863-a3f701b6797b
DOI: 10.1101/2024.05.15.594343

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