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Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

13 Sept 2022

Abstract excerpt

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC) homeostasis; however, the understanding of how different cell populations contribute to this process is limited. Here, we utilized single-cell RNA sequencing to provide insight into cellular composition changes within isolated pulmonary arteries (PAs) from pulmonary arterial hypertension and donor lungs. Our results revealed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 36099047
DOI: 10.1172/jci.insight.153471

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