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Article

Multi-omics integration study of vascular smooth muscle cell phenotypic conversion identified novel biomarkers in idiopathic pulmonary arterial hypertension.

Respiratory research - 12 Feb 2026

Wu Ruhao, Wang Ke, Fan Mingwei, Jia Ruohan, Ma Yuanying, Yuan Congying, Yu Meichen, Guo Mingzhou, Jiang Tianci, Wang Yu, Li Yue, Li Pengfei, Liu Yichen, Gong Youyou, Cheng Zhe

Abstract excerpt

BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is a progressive, high‑mortality disease driven in part by maladaptive vascular remodeling. Phenotypic conversion of vascular smooth muscle cells (VSMCs) is implicated in this process, but the cellular heterogeneity and regulatory drivers in IPAH remain incompletely defined. METHODS: We integrated scRNA‑seq datasets from IPAH and control lungs samples...

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Identifiers

PMID: 41673666
DOI: 10.1186/s12931-026-03568-8
PMCID: PMC12997889

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