Article

Drug Contraindications in Comorbid Diseases: a Protein Interactome Perspective

2022-01-15

Abstract excerpt

Adverse drug reactions (ADRs) are leading causes of death and drug withdrawals and frequently cooccur with comorbidities. However, systematic studies on the effects of drugs in comorbidities are lacking. Drug interactions with the cellular protein-protein interaction (PPI) network give rise to ADRs. We selected 6 comorbid disease pairs, identified the drugs used in the treatment of the individual diseases ‘A’ and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae7da4bb-9dcb-5f1f-a155-c78228a87b24
DOI: 10.1101/2022.01.11.475465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug Contraindications in Comorbid Diseases: a Protein Interactome PerspectiveDOI 10.1101/2022.01.11.475465Read

Targeting comorbid diseases via network endopharmacologySemantic proximity Read

The Use of Different Types of Networks, Alone and in Combination, for Drug Target IdentificationSemantic proximity Read

Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profilesSemantic proximity Read

A comprehensive assessment of the association between common drugs and psychiatric disorders using Mendelian randomization and real-world pharmacovigilance database.Semantic proximity Read

Relating drug-protein interaction network with drug side effects.Semantic proximity Read

The role of antipsychotics and other drugs on the development and progression of Neuroleptic Malignant SyndromeSemantic proximity Read

DREAMER: Exploring Common Mechanisms of Adverse Drug Reactions and Disease Phenotypes through Network-Based AnalysisSemantic proximity Read

D4: Deep Drug-drug interaction Discovery and DemystificationSemantic proximity Read

Disentangling the contribution of disease genes to drug therapeutic and side effectsSemantic proximity Read

Identification of disease treatment mechanisms through the multiscale interactomeSemantic proximity Read

Prioritization of Potential Drugs Through Pathway-Based Drug Repurposing and Network Proximity AnalysisSemantic proximity Read

Drug target gene-based analyses of drug repositionability in rare and intractable diseases.Semantic proximity Read