Article

Identification of disease treatment mechanisms through the multiscale interactome

2020-05-02

Abstract excerpt

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins. How drugs restore these functions, however, is often unknown as a drug’s therapeutic effects are not limited only to the proteins that the drug directly targets. Here, we develop the multiscale interactome, a powerful approach to explain disease treatment. We integrate disease-perturbed prot...

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Literature Corpus work: 5b898d81-999e-57e5-8c39-ac892237a678
DOI: 10.1101/2020.04.30.069690

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