Article
Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis.
Cell reports methods - 24 Feb 2025
Firoozbakht Farzaneh, Elkjaer Maria Louise, Handy Diane E, Wang Rui-Sheng, Chervontseva Zoe, Rarey Matthias, Loscalzo Joseph, Baumbach Jan, Tsoy Olga
Abstract excerpt
The need for a deeper understanding of adverse drug reaction (ADR) mechanisms is vital for improving drug safety and repurposing. This study introduces Drug Adverse Reaction Mechanism Explainer (DREAMER), a network-based framework that uses a comprehensive knowledge graph to uncover molecular mechanisms underlying ADRs and disease phenotypes. By examining shared phenotypes of drugs and diseases and their effects...
Read the complete abstract on PubMedTopics
- Humans
- Drug-Related Side Effects and Adverse Reactions
- Phenotype
- Drug Repositioning
- Protein Interaction Maps