Targeting comorbid diseases via network endopharmacology

Abstract excerpt

The traditional drug discovery paradigm has shaped around the idea of “one target, one disease”. Recently, it has become clear that not only it is hard to achieve single target specificity but also it is often more desirable to tinker the complex cellular network by targeting multiple proteins, causing a paradigm shift towards polypharmacology (multiple targets, one disease). Given the lack of clear-cut boundaries...

Topics

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• Comorbidity
• Disease
• Drug Therapy
• Gene Expression
• Internet
• MicroRNAs
• Polymorphism, Single Nucleotide
• Software

Identifiers and source

Literature Corpus work

eb43ba89-40db-5e37-be0e-8d7327c7aaca

DOI

10.1101/313809