Disentangling the contribution of disease genes to drug therapeutic and side effects

Abstract excerpt

Most clinical trials fail due to either lack of efficacy or safety concerns. Human genetics can address both failure reasons: disease-associated genes are not only promising therapeutic targets but also predict drug side effects. However, because the same genetic signal underlies both outcomes, we need methods that disentangle which disease genes mediate therapeutic benefit versus adverse side effects. We use Drap...

Topics

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• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• Data Mining
• Disease
• Drug Repositioning
• Environment
• High-Throughput Screening Assays
• International Classification of Diseases

Identifiers and source

Literature Corpus work

444c8292-baf3-52dc-b051-2f948f37682a

DOI

10.64898/2026.05.04.26352378