Article

DREAMER: Exploring Common Mechanisms of Adverse Drug Reactions and Disease Phenotypes through Network-Based Analysis

2024-07-22

Abstract excerpt

Adverse drug reactions (ADRs) are a major concern in clinical healthcare, significantly affecting patient safety and drug development. The need for a deeper understanding of ADR mechanisms is crucial for improving drug safety profiles in drug design and drug repurposing. This study introduces DREAMER (Drug adverse REAction Mechanism ExplaineR), a novel network-based method for exploring the mechanisms underlying a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf73b073-6c3e-5bed-af09-4c90ad598070
DOI: 10.1101/2024.07.20.602911

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DREAMER: Exploring Common Mechanisms of Adverse Drug Reactions and Disease Phenotypes through Network-Based AnalysisDOI 10.1101/2024.07.20.602911Read

D4: Deep Drug-drug interaction Discovery and DemystificationSemantic proximity Read

Explainable drug side effect prediction via biologically informed graph neural networkSemantic proximity Read

Computational Prediction of Drug Phenotypic Effects Based on Substructure-Phenotype Associations.Semantic proximity Read

Analysis and Mining of Baloxavir Marboxil Adverse Event Signals in Elderly Patients Based on the FAERS DatabaseSemantic proximity Read

Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.Semantic proximity Read

Disentangling the contribution of disease genes to drug therapeutic and side effectsSemantic proximity Read

APRILE: Exploring the Molecular Mechanisms of Drug Side Effects with Explainable Graph Neural NetworksSemantic proximity Read

Analysis and Mining of Baloxavir Marboxil Adverse Event Signals in Elderly Patients Based on the FAERS DatabaseSemantic proximity Read

Drug voyager: a computational platform for exploring unintended drug action.Semantic proximity Read

Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian PopulationSemantic proximity Read

A transformer model explaining mechanisms of drug therapeutic and adverse effectsSemantic proximity Read

Quantifying the severity of adverse drug reactions using social mediaSemantic proximity Read