Article

Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profiles

2018-09-30

Abstract excerpt

Comorbidity is an impactful medical problem that is attracting increasing attention in healthcare and biomedical research. However, little is known about the molecular processes leading to the development of a specific disease in patients affected by other conditions. We present a disease interaction network inferred from similarities in patients’ molecular profiles, which significantly recapitulates epidemiologic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96b2ac22-3e59-5e07-a877-3e1edc171154
DOI: 10.1101/431312

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profilesDOI 10.1101/431312Read

Interpreting molecular similarity between patients as a determinant of disease comorbidity relationships.Semantic proximity Read

Patient stratification reveals the molecular basis of disease comorbiditiesSemantic proximity Read

Genetic and functional characterization of disease associations explains comorbidity.Semantic proximity Read

Discovering comorbid diseases using an inter-disease interactivity network based on biobank-scale PheWAS data.Semantic proximity Read

PCID: A Novel Approach for Predicting Disease Comorbidity by Integrating Multi-Scale Data.Semantic proximity Read

Biomechanisms of Comorbidity: Reviewing Integrative Analyses of Multi-omics Datasets and Electronic Health Records.Semantic proximity Read

Identification of disease comorbidity through hidden molecular mechanisms.Semantic proximity Read

A global overview of genetically interpretable comorbidities among common diseases in UK BiobankSemantic proximity Read

LeMeDISCO is a computational method for large-scale prediction & molecular interpretation of disease comorbidity.Semantic proximity Read

LeMeDISCO: A computational method for large-scale prediction & molecular interpretation of disease comorbiditySemantic proximity Read

Sex-specific transcriptome similarity networks elucidate comorbidity relationshipsSemantic proximity Read

Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks.Semantic proximity Read