Article

Cell-type-resolved Metabolic Flux Inference Reveals Stromal Metabolic Reprogramming Across Human Cardiomyopathies

2026-04-21

Abstract excerpt

Metabolic remodeling is a hallmark of cardiomyopathy, yet which cell types bear the metabolic burden and how cell-type-specific contributions are disrupted remain unclear. Here, we developed a cell-type-resolved genome-scale metabolic flux inference pipeline optimized for post-mitotic cardiac tissue by maximizing ATP synthesis rather than biomass production and applied it to a single-nucleus transcriptomic atlas o...

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Literature Corpus work: 63f2f28d-9422-5dc7-a9c2-46b3891aa9f3
DOI: 10.64898/2026.04.19.719409

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