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Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

14 Mar 2023

Abstract excerpt

Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as a hallmark of malignancy, but recent studies have shed light on its role in cardiovascular diseases (CVDs). Various metabolic pathways in cardiomyocytes and noncardiomyocytes determine cellular senescence in the aging heart. Metabolic alteration is a common...

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PMID: 36918543
DOI: 10.1038/s41392-023-01378-8

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