Article

Unravelling drug resistant proteotypes through phenotype-resolved proteomics of single-cell derived colonies

2025-10-13

Abstract excerpt

<h4>Summary</h4> Drug resistance in cancer therapy continues to significantly contribute to treatment failure and disease progression, and is linked to intratumoral heterogeneity. Mass spectrometry (MS)-based single-cell proteomics (SCP) provides a unique opportunity to uncover the mechanisms underlying drug-resistant phenotypes; however, current methods lack clonal resolution and are often confounded by cell cyc...

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Literature Corpus work: ae6d3b46-1518-52c6-b9f0-328b85da31de
DOI: 10.1101/2025.10.11.681009

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