Article

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells

2018-02-21

Abstract excerpt

<h4>Summary</h4> We describe the rapid and reproducible acquisition of quantitative proteome maps for the NCI-60 cancer cell lines and their use to reveal cancer biology and drug response determinants. Proteome datasets for the 60 cell lines were acquired in duplicate within 30 working days using pressure cycling technology and SWATH mass spectrometry. We consistently quantified 3,171 SwissProt proteotypic protei...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e03db9eb-7a67-5ce9-a53d-418a528bfc9b
DOI: 10.1101/268953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cellsDOI 10.1101/268953Read

Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set.Semantic proximity Read

Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilitiesSemantic proximity Read

Large-scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell LinesSemantic proximity Read

Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell LinesSemantic proximity Read

Pan-cancer proteogenomics expands the landscape of therapeutic targetsSemantic proximity Read

Master regulators governing protein abundance across ten human cancer typesSemantic proximity Read

Unravelling drug resistant proteotypes through phenotype-resolved proteomics of single-cell derived coloniesSemantic proximity Read

CancerProteome: a resource to functionally decipher the proteome landscape in cancerSemantic proximity Read

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays.Semantic proximity Read

Data-independent Acquisition-based Proteome and Phosphoproteome Profiling across Six Melanoma Cell Lines Reveals Determinants of ProteotypesSemantic proximity Read

Quantitative Proteomics of the Cancer Cell Line Encyclopedia.Semantic proximity Read

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug PerturbationsSemantic proximity Read