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Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

16 Jun 2016

Abstract excerpt

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to be efficiently killed by therapy. Otherwise, even small surviving subpopulations may cause repopulation and...

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PMID: 27322289
DOI: 10.3390/ph9020033

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