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Article

Trait variability of cancer cells quantified by high-content automated microscopy of single cells.

Methods in enzymology - 1 Jan 2009

Quaranta Vito, Tyson Darren R, Garbett Shawn P, Weidow Brandy, Harris Mark P, Georgescu Walter

Abstract excerpt

Mapping quantitative cell traits (QCT) to underlying molecular defects is a central challenge in cancer research because heterogeneity at all biological scales, from genes to cells to populations, is recognized as the main driver of cancer progression and treatment resistance. A major roadblock to a multiscale framework linking cell to signaling to genetic cancer heterogeneity is the dearth of large-scale,...

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Identifiers

PMID: 19897088
DOI: 10.1016/S0076-6879(09)67002-6
PMCID: PMC2915824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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