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Article

AI-driven integration of genomic and exposome data for cancer risk: the combined risk score (CRS).

Human genomics - 4 May 2026

Sarigiannis Dimosthenis, Boukovinas Ioannis, Kaparelou Maria, Dimopoulos Athanasios-Meletios, Psaltopoulou Theodora, Pienta Kenneth J, Anesti Ourania, Karakitsios Spyros

Abstract excerpt

Polygenic risk scores (PRS) have emerged as important tools for quantifying inherited susceptibility to cancer, and are increasingly combined with environmental and lifestyle factors into composite risk scores (CRS). In this context, environmental inputs should be understood not as isolated covariates, but as components of the human exposome, encompassing cumulative, time-varying, and interacting exposures across...

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Identifiers

PMID: 42083001
DOI: 10.1186/s40246-026-00969-0
PMCID: PMC13289478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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