Article

Alternative super-enhancers result in similar gene expression in different tissues

2018-05-25

Abstract excerpt

Super-enhancers (SEs) are clusters of highly active enhancers, regulating cell type-specific and disease-related genes, including oncogenes. The individual regulatory regions within SEs might be simultaneously bound by different transcription factors (TFs) and co-regulators such as P300, BRD4 and Mediator, which together establish a chromatin environment conducting to effective gene induction. While cells with dis...

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Literature Corpus work: 0e21bf03-55df-5ab8-bb26-2c2868362671
DOI: 10.1101/329987

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