Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer

11 Dec 2019

Abstract excerpt

Forkhead box A1 (FOXA1) is a pioneer factor that facilitates chromatin binding and function of lineage-specific and oncogenic transcription factors. Hyperactive FOXA1 signaling due to gene amplification or overexpression has been reported in estrogen receptor-positive (ER + ) endocrine-resistant metastatic breast cancer. However, the molecular mechanisms by which FOXA1 up-regulation promotes these processes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to FOXO transcription factor regulation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31826955
DOI: 10.1073/pnas.1911584116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancerPMID 31826955Read ↗

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer.Semantic proximity Read ↗

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancerSemantic proximity Read ↗

Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast CancerSemantic proximity Read ↗

An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast CancerSemantic proximity Read ↗

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.Semantic proximity Read ↗

Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancerSemantic proximity Read ↗

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.Semantic proximity Read ↗

A Unique FOXA1-Associated Chromatin State Dictates Therapeutic Resistance in Lobular Breast CancerSemantic proximity Read ↗

The estrogen receptor/GATA3/FOXA1 transcriptional network: lessons learned from breast cancerSemantic proximity Read ↗

Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast CancerSemantic proximity Read ↗

FoxA1 is a Key Mediator of Hormonal Response in Breast and Prostate CancerSemantic proximity Read ↗

Estrogen Receptor Enhancers Sensitive to Low Doses of Hormone Specify Distinct Molecular and Biological OutcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.