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Autoimmune regulator and self‐tolerance – molecular and clinical aspects

18 Apr 2016

Abstract excerpt

The establishment of central tolerance in the thymus is critical for avoiding deleterious autoimmune diseases. Autoimmune regulator (AIRE), the causative gene in autoimmune polyendocrine syndrome type-1 (APS-1), is crucial for the establishment of self-tolerance in the thymus by promoting promiscuous expression of a wide array of tissue-restricted self-antigens. This step is critical for elimination of...

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PMID: 27088911
DOI: 10.1111/imr.12419

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