Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice.

PloS one - 1 Jan 2017

Huang Hu, Liu Ying, Wang Lei, Li Wen

Abstract excerpt

The role of chemokine receptor in age-related macular degeneration (AMD) remains elusive. The objective of this study is to investigate the role of chemokine receptor Cxcr5 in the pathogenesis of AMD. Cxcr5 gene expression levels (mRNA and protein) are higher in the retina and retinal pigment epithelium (RPE) of aged C57BL/6 wild type mice than younger ones. Vascular and glial cells express Cxcr5 and its ligand...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cis-trans-Isomerases
Share to Fundus Oculi
Share to Lipid Droplets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipofuscin

Share to Melanosomes

Share to Phagosomes

Share to Photoreceptor Cells

Share to Retinal Pigment Epithelium

Source

Open in PubMed Open full text

Identifiers

PMID: 28282423
DOI: 10.1371/journal.pone.0173716
PMCID: PMC5345864

Genes

RPE
ERG
RPE65
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice.PMID 28282423Read ↗

Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE HomeostasisSemantic proximity Read ↗

CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age.Semantic proximity Read ↗

CCR1 Signaling as a Common Injury Pathway in Retinal DegenerationSemantic proximity Read ↗

Molecular pathology of age-related macular degeneration.Semantic proximity Read ↗

Investigating Chemokine-Induced NF-κB Activation in Retinal Cells and Its Contribution to Age-Related Macular Degeneration Pathogenesis: A Systematic ReviewSemantic proximity Read ↗

Retinal and choroidal capillaries contribution to age-related macular degeneration (AMD) phenotypes in murine models of the disease.Semantic proximity Read ↗

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Semantic proximity Read ↗

A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD) Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5.Semantic proximity Read ↗

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degenerationSemantic proximity Read ↗

Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration.Semantic proximity Read ↗

The Dry Form of Age-Related Macular Degeneration (AMD): The Current Concepts of Pathogenesis and Prospects for Treatment.Semantic proximity Read ↗

CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.