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Amyloid β-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Hippocampal Neuronal Activity

2023-10-16

Abstract excerpt

Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive functions. Soluble Amyloid-beta Oligomers (AβOs), the main synaptotoxins engaged in the pathogenesis of Alzheimer&#039;s disease, generate aberrant Ca2+ signals in primary hipp...

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Literature Corpus work
ae027655-a0e7-5901-a68b-d5e28bc3ce51
DOI
10.20944/preprints202310.0984.v1
Open publication

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Amyloid β-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Hippocampal Neuronal ActivityDOI 10.20944/preprints202310.0984.v1
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