Article

Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis

2023-02-22

Abstract excerpt

Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration. aSyn-O can induce Ca 2+ influx, over activating downstream pathways leading to PD phenotype. Calcineurin (CN), a phosphatase regulated by Ca 2+ levels, activates NFAT transcription factors that are involved in the regulation of neuronal plasticity, growth and...

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Literature Corpus work: be5b322a-367e-51f4-840a-15ad611556ba
DOI: 10.1101/2023.02.21.529374

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